FAVRE-RACOUCHOT SYNDROME IN A UNILATERAL, PERIORAL DISTRIBUTION ASSOCIATED WITH TOBACCO USE: A CASE REPORT AND REVIEW Favre-Racouchot Syndrome in a Unilateral, Perioral Distribution Associated with Tobacco Use: A Case Report and Review

Figure 1. Small cysts and open comedones in an agminate arrangement post shave biopsy. Figure 2. Photomicrograph of skin containing two mildly inflamed comedonal cysts embedded in a dermis with evidence of severe solar damage (4x). Figure 3. Photomicrograph of the surrounding dermis demonstrating severe nodular solar elastosis indicating significant prolonged sun exposure (20x). Abstract The development of Favre-Racouchot syndrome (FRS) has been well described in dermatologic literature as having a strong association with chronic sun exposure and ultraviolet damage, which result in the classic appearance of solar elastosis and dilated open comedones in a bilateral periorbital distribution. However, frequently lacking in the literature is mention of another potential risk factor: tobacco use. The authors report a unique case presentation of FRS in a unilateral perioral distribution in a 66-year-old African American female without history of chronic sun exposure, but rather associated with preferential one-sided placement of her cigarettes. It is hoped that this case report will serve to strengthen the evidence that tobacco use may be implicated in the development of FRS.